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KMID : 0352519950320030316
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Korea Univercity Medical Journal
1995 Volume.32 No. 3 p.316 ~ p.325
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The Study of Oncogene and Growth Factors on Various Liver Diseases
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Jeon Woo-Ki
Yeom Bom-Woo
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Abstract
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The current concept of the carcinogenesis is that activated oncogenes or mutation of suppressor genes might inhibit the programmed cell death and permit cells to live forever. There are structural and functional similarities between the oncogenes and growth factors. Both substances act their functions by autocrine and paracrine effects on target cells and they appear in fetal, regenerating and sometimes in normal cells. In this study, I tried to find out which oncogenes and growth factors are involved in the process of carcinogenesis of the human liver. 53 cases of needle biopsied or resected liver specimens were used in immunohistologic study with anti sera of c-H-ras, c-myc. erbB2 and bcl-2 and antisera of TGFα and EGF.
The results are as followings.
1. The antisera of EGF and TGFα revealed positive reaction on most of the normal liver tissue, hepatitis, cirrhosis and hepatoma.
2. The c-myc anti serum reveals positive reaction on only two cases of hepatoma.
3. c-H-ras antiserum revealed positive reaction on 1 case of CAH, cirrhosis and hepatoma.
4. The antisera of erbB2 and bcl-2 revealed negative reaction on all liver tissues. These findings are highly suggestive that c-H-ras and c-myc are responsible for causative oncogenes of hepatoma rather than bcl-2 and erbB2.
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KEYWORD
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